Unisom and B6 dosage for morning sickness

How do the options compare?

The lens is a clinician's: guideline endorsement, pregnancy evidence, dosing, onset, and tolerability. Cost and formulation notes appear where relevant.

• ACOG recommends 10 to 25 mg of vitamin B6, three or four times a day, for nausea and vomiting in pregnancy, per the NIH Office of Dietary Supplements. 1
• Two randomized, placebo-controlled trials found that 30 to 75 mg of oral pyridoxine a day significantly decreased nausea in pregnant women, which brackets the range above. 1
• In the randomized trial of the combination product, each tablet held 10 mg of doxylamine and 10 mg of pyridoxine, participants took two tablets on the first night, and dosing rose to as many as four tablets daily based on symptom scores. 2
• Studies of hundreds of thousands of women have shown that doxylamine succinate with pyridoxine hydrochloride in pregnancy does not increase the chance of birth defects, and follow-up of children from ages 2 to 7 has not found a higher chance of behavior or learning problems. 3
• Nausea and vomiting of pregnancy usually begins between 4 and 9 weeks, peaks between 7 and 12 weeks, and goes away between 12 and 16 weeks for most people, which is the arc any dosing schedule is riding. 4

Which option makes sense?

The comparison above is intentionally evidence-first, not brand-first. Please consult your healthcare provider to translate it into a plan that fits your pregnancy specifics.

Disclosure: Pregnancy Smart offers a supplement that overlaps with one or more options above. This page describes the pregnancy evidence for each option on its own merits.