Diclegis vs Unisom and B6 for morning sickness

How do the options compare?

Each option is graded against five practical criteria: obstetric guideline support, pregnancy evidence depth, dose transparency, expected onset, and interactions that require provider coordination.

• Each Diclegis delayed-release tablet contains 10 mg doxylamine succinate and 10 mg pyridoxine hydrochloride, starts at two tablets at bedtime, and tops out at four tablets daily taken one in the morning, one mid-afternoon, and two at bedtime. 1
• Studies of hundreds of thousands of pregnancies have shown that doxylamine succinate with pyridoxine hydrochloride does not increase the chance of birth defects. 2
• A Unisom SleepTab is doxylamine succinate 25 mg, labeled as one tablet taken 30 minutes before bed, and its own package tells pregnant or breastfeeding users to ask a health professional before use. 3
• The delayed-release combination was approved by the FDA in April 2013 after a randomized placebo-controlled trial, in which somnolence appeared in 14.5% of the active group against 11.8% on placebo. 4
• Vitamin B6 supplements are most often pyridoxine hydrochloride, the pregnancy RDA is 1.9 mg a day, and the adult upper limit is 100 mg a day. 5

Which option makes sense?

The findings above apply to the populations and circumstances studied. They do not establish that every compared option is appropriate for you. Please consult your healthcare provider before acting on this summary.

Disclosure: Pregnancy Smart makes supplements in this category. The comparison above is written to inform, not to steer readers toward or away from our brand.