Symptom guide · Pregnancy Smart
Nausea in the second trimester
By trimester
Weeks 14–27
2nd trimester
For most people, nausea gradually fades by now. When it doesn't, common causes to check include reflux, gallbladder discomfort, and less often, thyroid or infection-related issues. Check in with your provider if nausea is new or getting worse in the second trimester.
What does the evidence show for nausea in the second trimester?
- Nausea and vomiting typically resolve by about 14 weeks for most people, though some continue to have symptoms into and through the second trimester. 1
- If an anti-nausea medicine like doxylamine plus B6 is working, it's fine to keep using it as long as symptoms need it, rather than stopping at some fixed week. 2
- If nausea first starts at 10 weeks or later, rather than easing off by then, it might have a different cause and is worth discussing with your healthcare provider. 3
- The FDA-approved combination of doxylamine and B6 (Diclegis) is approved for pregnancy nausea and can be continued past the first trimester when your provider directs it. 4
When should I call my provider about nausea in the second trimester?
By the second trimester most nausea is on its way out, so the pattern worth attention here is nausea that arrives new rather than nausea that lingers. MotherToBaby notes that symptoms first starting at the 10th week or later may be due to other causes, which makes brand-new second-trimester queasiness a reason to be checked rather than ridden out. Move the call earlier if nausea is blocking food, fluids, sleep, or a normal day. Relentless vomiting with weight loss and dehydration is the hyperemesis gravidarum picture, and hospitalization is part of that story. Trust your read on your own body. If something feels off beyond the list above, please consult your healthcare provider rather than waiting it out.
Frequently asked questions
Why is my nausea worse instead of better in the second trimester?
Reflux, gallbladder discomfort, and less commonly, thyroid or infection issues can all show up as ongoing nausea at this stage. A check-in with your provider helps sort out what's going on and what to do next.
Is it safe to keep taking doxylamine + B6 into the second trimester?
Yes, with your provider's guidance. Both ingredients have extensive pregnancy-safety data supporting continued use for as long as you need it.
Should I stop ginger or vitamin B6 at 14 weeks?
There's no automatic reason to stop. Taper based on how you're feeling, stay within the 100 mg/day upper limit for vitamin B6, and confirm your plan with your provider.
When is nausea a red flag rather than a nuisance?
Call your provider the same day for weight loss, not being able to keep fluids down for 12+ hours, fever, upper-right belly pain, yellowing skin, or vomiting blood.
Related in the library
Ingredients
Ginger root extract in pregnancy: evidence and safety
Ingredients
Vitamin B6 in pregnancy: evidence and safety
Symptoms
Morning Sickness (First Trimester)
Symptoms
Nausea in the third trimester
Symptoms
Heartburn during pregnancy
Is it safe?
Is ginger safe during pregnancy?
Is it safe?
Is vitamin B6 safe during pregnancy?
References
Morning Sickness: Nausea and Vomiting of Pregnancy (ACOG FAQ)
ACOG · https://www.acog.org/womens-health/faqs/morning-sickness-nausea-and-vomiting-of-pregnancy
ACOG Practice Bulletin: Nausea and Vomiting of Pregnancy
ACOG · https://www.acog.org/clinical/clinical-guidance/practice-bulletin/articles/2018/01/nausea-and-vomiting-of-pregnancy
Nausea and Vomiting in Pregnancy (NVP): MotherToBaby Fact Sheet
MotherToBaby · https://mothertobaby.org/fact-sheets/nausea-vomiting-pregnancy-nvp/
Diclegis (doxylamine succinate and pyridoxine hydrochloride) Prescribing Information: FDA
FDA · https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021876s002lbl.pdf
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
