Is Humira (Adalimumab) Safe During Pregnancy?

What does the evidence say about humira during pregnancy?

1. MotherToBaby says most studies do not suggest an increased miscarriage chance or birth-defect pattern with adalimumab, while disease activity can complicate interpretation. 1
2. A prospective cohort of 257 adalimumab-exposed pregnancies compared with disease-matched controls did not identify increased adverse birth outcomes attributable to adalimumab. 2
3. A post-marketing Crohn’s disease registry analysis reported pregnancy outcomes without an additional adverse pattern in its observed pregnancies. 3
4. A third-trimester inflammatory bowel disease study compared continuation and discontinuation and reported no higher infant respiratory infection signal with continuation, though the result does not prove equivalence. 4
5. Adalimumab crosses the placenta more during the third trimester, so the infant’s care team should know about late exposure when discussing vaccines and infection monitoring. 1

Is humira safe in each trimester?

• First trimester. Discuss ongoing Humira with the prescribing specialist and prenatal clinician early in pregnancy. Disease control and the reason for adalimumab matter when weighing a plan.
• Second trimester. The team can review response, infection history, and the timing of doses. Available studies do not show a consistent increase in major pregnancy problems, but individual decisions remain clinical.
• Third trimester. Late-pregnancy dosing and infant vaccine planning should be coordinated with the prescriber and pediatric team because placental transfer is greater later in pregnancy.